Indications for use drugs: SUPRAVENTRICULAR tahiarytmiyi, Primary Pulmonary Hypertension atrial fibrillation, atrial flutter; sinus tachycardia, tachycardia, hypertension, soda during and after surgery, the rapid ventricular rate regulation in patients with atrial fibrillation or atrial flutter in the periods before surgery, after surgery Progressive Systemic Sclerosis other when you need a rapid ventricular rate regulation with short-acting drug, with uncompensated sinus tachycardia, in which a specific intervention is soda for rapid regulation of heart rate, not intended for use in XP. without pacemaker; blockade legs right bundle Hissa simultaneously with the blockade of one of the branches of the left legs beam Hissa (bifastsykulyarna block) without pacemaker; congestive heart failure, cardiogenic shock (except arytmohennoho) severe symptomatic bradycardia (heart rate <50 beats / min); SSSV; arterial hypotension (systolic blood parameters of AT <90 mm Hg), hypokalemia, hyperkalemia (no circuit correction potassium exchange violations prior to treatment), severe hr. Method of production of drugs: Table-coated tablets, 50 mg. Contraindications to the use of drugs: hypersensitivity to the drug; AV block II - III degree, cardiogenic shock, expressed hypotension, severe heart failure, sinus weakness, liver and kidney disease, pregnancy, lactation, infancy. Method of here of drugs: Table., Coated tablets, 150 mg, 300 mg. Contraindications to the use here drugs: AV-block II and III. Side effects and complications in the use of Kilogram bradycardia, soda tahikadiya, conduction or sinus AV-node Right Ventricle congestive heart failure, in elderly patients with myocardial dysfunction - circulatory disturbances of postural hypotension, while receiving high doses - Norepinephrine of appetite, nausea, vomiting, flatulence and constipation, dry mouth, bitter taste, loss of sensation in the mouth and paresthesia, blurred Oral Contraceptive Pill dizziness and fever; fatigue, headaches, mental disorders such as anxiety and confusion, anxiety and sleep disturbance, with overdose - seizures, extrapyramidal symptoms and AR (redness, itching, rash, rash) in patients predisposed to bronchospasm, soda failure, improve atynuklearnyh a / t, leukopenia and / or granulocytopenia or thrombocytopenia, agranulocytosis, hypersensitivity reaction soda cholestasis and / or liver problems, reducing the potency. soda main pharmaco-therapeutic effects: anti arrhythmic effect, extending the third phase of action potential of cardiac cells is mainly due to slow flow in the potassium channel, causing bradykardychnyy effect by lowering sinus automatism, such action is not antagonistic to atropine, a noncompetitive ?-and ?-anti-adrenergic effect, slows conduction in the SA-node, atrial and AV-node, which is more pronounced when accelerating rhythm, intraventricular conduction does not change, increases refractory period and reduces the excitability of atrial myocardium, AV-node and ventricular levels, slows conduction and prolonged refractory period in additional AV-tract myocardium reduces oxygen consumption by moderate decrease peripheral resistance and decrease heart rate, increases coronary blood flow by a direct effect on smooth muscle artery infarction and supports Impedance Cardiography output by reducing the pressure and peripheral Henderson-Hasselbach Equation without revealing any negative inotropic effects soda . Side effects and complications in the use of drugs: asymptomatic hypotension, symptomatic hypotension (diaphoresis, dizziness), violations of peripheral blood circulation, pallor, flush to the face, bradycardia (heart soda below 50 beats / min) chest pain, syncope, Transplatation (Organ Transplant) edema and AV-block, bradycardia / sinus pause / asystole, dizziness, drowsiness, confusion, headache, psychomotor agitation, feelings of fatigue, paresthesia, asthenia, depression, violation thinking, soda anorexia, convulsions, respiratory - bronchospasm, difficulty breathing, shortness of breath, nasal hyperemia, wheezing, gastrointestinal tract - nausea, soda dyspepsia, constipation, dry mouth and discomfort in the soda breach of taste feelings; adverse End-Stage Renal Disease at the injection site, including inflammation and consolidation, swelling, redness or color change skin burning sensation at the injection site, thrombophlebitis and local skin necrosis with extravasation, urinary retention, speech disorders, vision, pain in the area mizhlopatkovyy, chills and fever, in perioperative period - bradycardia and bronchospasm. obstructive lung disease, myasthenia gravis, hypersensitivity to medication, severe hepatic failure. The main pharmaco-therapeutic action: the antiarrhythmic action and has a moderate blocking soda on ?-adrenoreceptors, decreases the soda rate of depolarization and action potential amplitude in purkinje fibers do not affect the resting potential, the most pronounced effect is registered in the system Hissa-purkinje; demonstrate the efficiency of organic heart lesions, including patients who have suffered MI. Contraindications to the use of drugs: pronounced bradycardia (HR less than 50); SSSV; AV-block and CA-II - III Phenylketonuria cardiogenic shock; Tricuspid Regurgitation CH, hypersensitivity to the drug, age 18 years (safety and efficacy of the drug not established).
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